Kyowa Kirin International is headquartered in the Scottish Borders with full commercial operations in the UK and Ireland.
We have a range of products in the UK and Ireland, covering the following therapeutic areas:
XLH, or X-linked hypophosphataemia, is a rare, hereditary, chronic and progressive musculoskeletal disorder resulting from excess FGF23 production. In XLH, excessive levels of FGF23 result in renal phosphate wasting and decreased active vitamin D levels, causing chronic hypophosphataemia. In the majority of cases XLH is inherited in an X-linked pattern and it is estimated to affect approximately 1 in 20,000 to 1 in 60,000 people. XLH is associated with functional limitations and a reduced quality of life.
Wernicke’s encephalopathy is an acute neurological disorder caused by thiamine deficiency due to alcohol misuse. In developed countries, 30-80% of alcohol misusers have reduced circulating thiamine levels. If Wernicke’s encephalopathy is left untreated, it can get worse very quickly, and may even lead to permanent brain damage and death.
CINV is a common side effect of cytotoxic (conventional) cancer therapy and is one of the most distressing side effects for patients. A number of CINV types have been reported, according to time of onset, patient experience and relationship to antiemetic therapy. CINV is a serious problem and may be associated with impaired quality of life and delays to scheduled chemotherapy.
Osteoporosis, which literally means porous bone, is a disease in which the density and quality of bone are reduced. As bones become more porous and fragile, the risk of fracture is greatly increased. The loss of bone occurs silently and progressively. Often there are no symptoms until the first fracture occurs.
Vitamin D is essential for strong bones, because it helps the body use calcium from the diet. Traditionally, vitamin D deficiency has been associated with rickets, a disease in which the bone tissue doesn’t properly mineralize, leading to soft bones and skeletal deformities.
Many people who are suffering from cancer will experience regular pain. This ongoing and continuous pain is sometimes called ‘background pain’. However, some people whose background pain is relieved by medication may also experience periods of particularly severe and intense pain that ‘breaks through’ their background pain medication. Breakthrough cancer pain usually comes on very quickly and can be severe and intense, but rarely lasts more than 30 minutes. It can be related to specific activities, such as medical procedures or patient movement (incident pain) or may occur randomly (spontaneous pain).
Opioids are a major class of analgesics often used to relieve severe pain. One of the most common side effects of opioids is constipation. Opioid-induced constipation may not respond adequately to laxatives because of its distinct cause.
An anal fissure is a common and often painful problem caused by a small tear or ulcer (open sore) in the lining of the anus (back passage). This can cause bleeding, local itching and pain with a bowel movement, which can be severe. Anal fissures usually heal within a few weeks but those that have not healed after 4–6 weeks are called chronic fissures.
Testosterone Deficiency Syndrome is a medical condition where the body does not produce enough of the male hormone testosterone. It can be accompanied by symptoms such as low sex drive, fatigue, low mood and erectile dysfunction. Testosterone is produced naturally by the testicles and is important for physical and emotional well-being. It is responsible for many things in the body including maintaining muscle and bone mass, the production of sperm, and the desire to have sex.
Sweating is necessary to control body temperature during times of exercise and in warm /hot surroundings, and is a normal response to a rise in temperature or anxiety. Sweating is regulated by the sympathetic nervous system. In about 1 % of the population sweating occurs at inappropriate times, far in excess of the amount necessary to maintain normal body temperature. This condition is known as Hyperhidrosis, which means ‘excessive sweating’.
Over 10,000 people are diagnosed with bladder cancer each year. Most cases (over 70%) are diagnosed at an early stage known as superficial, or Non-Muscle-Invasive Bladder Cancer, which is a cancer that has not spread from the surface lining of the bladder into the surrounding muscle layer. Non-Muscle-Invasive Bladder Cancer may be treated in a number of ways, including surgery to remove the visible cancer and medication to help to reduce the risk of the cancer recurring or progressing.